Polymorphism identification, RH mapping, and association analysis with the anxiety trait of the equine serotonin transporter (SLC6A4) gene.

Association of STin2 VNTR Polymorphism in the SLC6A4 Gene with Increased Risk of MS Disease

Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) that is characterized by inflammation, demyelination and axonal injury. Although the etiology of MS disease is still unknown, many studies suggest that immune system dysfunction plays an important role in the pathogenesis of this disease. The serotonin serves as a mediator between CNS and the immune sys...

Correlation of serotonin transporter gene polymorphism with temperament in Persian medicine

Background: Despite its effectiveness, there are still many concerns and questions about the principles and therapeutic methods of traditional medicine (TM). In other words, in order to accept TM as a reliable health care system, its proficiency need to be declared through modern scientific research. One of the major determinants of Persian medicine (PM) which is practically utilized in disease...

Functional serotonin transporter gene polymorphisms and anxiety personality traits: new study and meta-analysis on a psychiatrically healthy population

Serotonin transporter genetic variation and the response of the human amygdala.

A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent. Serotonin [5- hydroxytryptamine, (5-HT)] function influences normal fear as well as pathologica...

Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression.

We studied the association between the short/long promotor-based length polymorphism of the serotonin transporter gene (5-HTTLPR) and neuroticism, anxiety and depression. Subjects included twins, their siblings and parents from the Netherlands Twin Register (559 parents and 1,245 offspring). Subjects had participated between one and five times in a survey study measuring neuroticism, anxiety an...